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Literature summary extracted from
- Structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development (2002), Proc. Natl. Acad. Sci. USA, 99, 6591-6596.
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 4.6.1.12 | vapor-diffusion hanging drop method, crystal structure of the zinc enzyme in complex with cytidine 5'-diphosphate and Mn2+ is determined to 1.8 A resolution | Escherichia coli |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.12 | Mn2+ | a Mn2+ with octahedral geometry, is positioned between the alpha and beta phosphates acting in concert with the Zn2+ to align and polarize the substrate for catalysis | Escherichia coli |  |
| 4.6.1.12 | Zn2+ | active site contains a Zn2+ with tetrahedral coordination | Escherichia coli | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.6.1.12 | Escherichia coli | P62617 | - |
- |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.6.1.12 | trimer | - |
Escherichia coli |
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Release 2023.1 (January 2023)
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